Established in year 2000, the Biomolecular NMR Facility is a core facility in the Department of Chemistry and Biochemistry at University of Maryland, College Park. The facility currently hosts three high field liquid NMR spectrometers and has the capability to run a wide range of NMR experiments. Its user base includes scientists from various fields such as organic chemistry, medicinal chemistry, biochemistry, biophysics, polymer science, material science and bioengineering.
The facility provides high field NMR instrumentation to support University of Maryland research community through measurements of biomolecules, macromolecules and systems of biological interest. It also provides advanced training opportunities for students and acts as a hub for interdisciplinary collaborations.
The facility provides fast and reliable high resolution liquid NMR analysis to internal and external users. Samples can be organic, inorganic, polymer, biomolecules... Details are on NMR Services webpage.
Dr. David Fushman
(Biophysical and Bioanalytical Chemistry, Theoretical and Computational Chemistry):
Development and application of new experimental and theoretical approaches to study structural properties, dynamics, interactions, and regulation in multi-domain systems; polyubiquitin signaling; structure determination and analysis of proteins, nuclear magnetic resonance (NMR) and relaxation; computational biology; molecular dynamics simulations, physical and mathematical modeling.
Dr. Kwaku Dayie
(Bioorganic Chemistry, Biophysical and Bioanalytical Chemistry, Enzymology, Structural Biology, and Theoretical Chemistry):
Structure, interactions, dynamics, and function of RNA complexes involved in catalysis and gene regulation; chemical biological methods of labeling RNAs; NMR methods development.
Dr. Lawrence Sita
(Materials Chemistry, Nanoscience and Supramolecular Chemistry, Organometallic Chemistry and Catalysis, Surface Chemistry, Polymer Science and Chemical Technology):
Synthetic, structural and mechanistic inorganic and organometallic chemistry; molecular and mesoscopic self-assembly processes; chemically modified surface and interfaces, polymer synthesis, development and utilization of low cost catalysts for commodity chemical production.
Dr. Herman Sintim
(Bioorganic and Natural Product Chemistry, Organic and Nucleic Acids Chemistry, Chemical Biology):
Natural product synthesis and synthetic methodology; small molecule inhibitors of bacterial virulence and biofilm formation; design of oligonucleotide probes to study RNA and DNA processing.
Dr. Paul Paukstelis
Nucleic acid structure, function, and catalysis. Structural DNA nanotechnology. RNA-protein interactions. Structure based drug design.