Established in year 2000, the Biomolecular NMR Facility is a core facility in the Department of Chemistry and Biochemistry at University of Maryland, College Park. The facility currently hosts three high field liquid NMR spectrometers and has the capability to run a wide range of NMR experiments. Its user base includes scientists from various fields such as organic chemistry, medicinal chemistry, biochemistry, biophysics, polymer science, material science and bioengineering.
The facility provides high field NMR instrumentation to support the UMCP research community through measurements of biomolecules, macromolecules and systems of biological interest. It also provides advanced training opportunities for students and acts as a hub for interdisciplinary collaborations.
The facility also provides fast and reliable sample NMR analysis to internal and external users.
- Main Users
- Dr. David Fushman
- Dr. Kwaku Dayie
- Dr. Vitali Tugarinov
- Dr. Herman Sintim
- Dr. Lawrence SitaMain users of the facility composed of a few PIs and their research group members.
Development and application of new experimental and theoretical approaches to study structural properties, dynamics, interactions, and regulation in multi-domain systems; polyubiquitin signaling; structure determination and analysis of proteins, nuclear magnetic resonance (NMR) and relaxation; computational biology; molecular dynamics simulations, physical and mathematical modeling.
Structure, interactions, dynamics, and function of RNA complexes involved in catalysis and gene regulation; chemical biological methods of labeling RNAs; NMR methods development.
Natural product synthesis and synthetic methodology; small molecule inhibitors of bacterial virulence and biofilm formation; design of oligonucleotide probes to study RNA and DNA processing.
Synthetic, structural and mechanistic inorganic and organometallic chemistry; molecular and mesoscopic self-assembly processes; chemically modified surface and interfaces, polymer synthesis, development and utilization of low cost catalysts for commodity chemical production.